000			04879cam a22004217i 4500
999			_c4348 _d4348
001			18466233
003			OSt
005			20250903143647.0
008			150127s2015 ne a b 001 0 eng d
010			_a 2015932023
016	7		_a101658031 _2DNLM
020			_a9780128011393
020			_a0128011394
035			_a(OCoLC)ocn900032402
040			_aKyU _beng _cKyUL _erda _dKyU
042			_anlmcopyc _alccopycat
050	0	0	_aRA1224.2 _b.E614 2015
060	0	0	_a2015 E-139
060	1	0	_aWK 102
082	0	4	_aRA1224.2 .D82 2015 _223
245	0	0	_aEndocrine disruption and human health / _cedited by Philippa D. Darbre, BScHons, PhD, School of Biological Sciences, University of Reading, Reading, UK.
264		1	_aAmsterdam ; _aBoston : _bAcademic Press, _c[2015]
300			_axii, 377 pages : _bcolor illustrations ; _c25 cm
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aOverview and scope: 1. What are the endocrine disrupters and where are they found? / Philippa D. Darbre -- 2. How could endocrine disrupters affect human health? / Philippa D. Darbre. Mechanisms and assay systems: 3. Disrupters of estrogen action and synthesis / Philippa D. Darbre -- 4. Disruptors of androgen action and synthesis / J. Thomas Sanderson -- 5. Disrupters of thyroid hormone action and synthesis / Jenny Odum -- 6. Disruption of other receptor systems: progesterone and glucocorticoid receptors, peroxisome preliferator-activated receptors, pregnane X receptor, and aryl hydrocarbon receptor / Philippa D. Darbre -- 7. Nonmonotonic responses in endocrine disruption / Laura N. Vendenburg. Concerns for human health: 8. Endocrine disruption and female reproductive health / Philippa D. Darbre -- 9. Endocrine disruption and male reproductive health / Philippa D. Darbre -- 10. Endocrine disruption and cancer of reproductive tissues / Philippa D. Darbre, Graeme Williams -- 11. Endocrine disruption of thyroid function: chemicals, mechanisms and toxicopathology / Catherine Sutcliffe, Philip W. Harvey -- 12. Endocrine disruption of adrenocortical function / Philip W. Harvey -- 13. Endocrine disruption of developmental pathways and children's health / Monica K. Silver, John D. Meeker -- 14. Effects of endocrine disrupters on immune function and inflammation / Rodney R. Dietert -- 15. Endocrine disruption and disorders of energy metabolism / Philippa D. Darbre. Public policy and regulatory considerations: 16. An introduction to the challenges for risk assessment of endocrine disrupting chemicals / Philippa D. Darbre -- 17. Regulatory considerations for endocrine disrupters in food / Gerard M. Cooke, Rekha Mehta -- 18. Considerations of endocrine disrupters in drinking water / Rowena H. Gee, Leon S. Rockett, Paul C. Rumsby -- 19. Regulatory considerations for dermal application of endocrine disrupters in personal care products / Philippa D. Darbre, Philip W. Harvey.
520			_aEndocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human healthPresents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human healthOffers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations.-- _cSource othe than Library of Congress.
650		0	_aEndocrine disrupting chemicals _xSchool of Health Sciences _2Health Science
650	1	2	_aEndocrine Disruptors _2Health Science _xSchool of Health Sciences
700	1		_aDarbre, Philippa D. _eeditor.
856	4	2	_3Publisher description _uhttps://www.loc.gov/catdir/enhancements/fy1614/2015932023-d.html
906			_a7 _bcbc _ccopycat _d2 _encip _f20 _gy-gencatlg
942			_2lcc _cLLB