04887cam a22004097i 4500999001500000001000900015003000400024005001700028008004100045010001700086016002000103020001800123020001500141035002400156040002900180042002400209050002500233060001500258060001100273082002700284245015600311264005100467300005100518336002600569337002800595338002700623504005100650505199900701520130702700650007804007650006804085700003304153856009204186906004504278942001304323952014104336  c4348d434818466233OSt20250903143647.0150127s2015    ne a     b    001 0 eng d  a  20159320237 a1016580312DNLM  a9780128011393  a0128011394  a(OCoLC)ocn900032402  aKyUbengcKyULerdadKyU  anlmcopycalccopycat00aRA1224.2b.E614 201500a2015 E-13910aWK 10204aRA1224.2 .D82 201522300aEndocrine disruption and human health /cedited by Philippa D. Darbre, BScHons, PhD, School of Biological Sciences, University of Reading, Reading, UK. 1aAmsterdam ;aBoston :bAcademic Press,c[2015]  axii, 377 pages :bcolor illustrations ;c25 cm  atextbtxt2rdacontent  aunmediatedbn2rdamedia  avolumebnc2rdacarrier  aIncludes bibliographical references and index.0 aOverview and scope: 1. What are the endocrine disrupters and where are they found? / Philippa D. Darbre -- 2. How could endocrine disrupters affect human health? / Philippa D. Darbre. Mechanisms and assay systems: 3. Disrupters of estrogen action and synthesis / Philippa D. Darbre -- 4. Disruptors of androgen action and synthesis / J. Thomas Sanderson -- 5. Disrupters of thyroid hormone action and synthesis / Jenny Odum -- 6. Disruption of other receptor systems: progesterone and glucocorticoid receptors, peroxisome preliferator-activated receptors, pregnane X receptor, and aryl hydrocarbon receptor / Philippa D. Darbre -- 7. Nonmonotonic responses in endocrine disruption / Laura N. Vendenburg. Concerns for human health: 8. Endocrine disruption and female reproductive health / Philippa D. Darbre -- 9. Endocrine disruption and male reproductive health / Philippa D. Darbre -- 10. Endocrine disruption and cancer of reproductive tissues / Philippa D. Darbre, Graeme Williams -- 11. Endocrine disruption of thyroid function: chemicals, mechanisms and toxicopathology / Catherine Sutcliffe, Philip W. Harvey -- 12. Endocrine disruption of adrenocortical function / Philip W. Harvey -- 13. Endocrine disruption of developmental pathways and children's health / Monica K. Silver, John D. Meeker -- 14. Effects of endocrine disrupters on immune function and inflammation / Rodney R. Dietert -- 15. Endocrine disruption and disorders of energy metabolism / Philippa D. Darbre. Public policy and regulatory considerations: 16. An introduction to the challenges for risk assessment of endocrine disrupting chemicals / Philippa D. Darbre -- 17. Regulatory considerations for endocrine disrupters in food / Gerard M. Cooke, Rekha Mehta -- 18. Considerations of endocrine disrupters in drinking water / Rowena H. Gee, Leon S. Rockett, Paul C. Rumsby -- 19. Regulatory considerations for dermal application of endocrine disrupters in personal care products / Philippa D. Darbre, Philip W. Harvey.  aEndocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human healthPresents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human healthOffers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations.--cSource othe than Library of Congress. 0aEndocrine disrupting chemicalsxSchool of Health Sciences2Health Science12aEndocrine Disruptors2Health SciencexSchool of Health Sciences1 aDarbre, Philippa D.eeditor.423Publisher descriptionuhttps://www.loc.gov/catdir/enhancements/fy1614/2015932023-d.html  a7bcbcccopycatd2encipf20gy-gencatlg  2lcccLLB  00102lcc40708NFICaKyUCLbKyUCLcGENd2020-10-07eDonationg13440.00oRA1224.2 .D82 2015pKyU/2020/7880r2022-02-16w2020-10-22yLLB