04879cam a22004217i 4500 4348 4348 18466233 OSt 20250903143647.0 150127s2015 ne a b 001 0 eng d 2015932023 101658031 DNLM 9780128011393 0128011394 (OCoLC)ocn900032402 KyU eng KyUL rda KyU nlmcopyc lccopycat RA1224.2 .E614 2015 2015 E-139 WK 102 RA1224.2 .D82 2015 23 Endocrine disruption and human health / edited by Philippa D. Darbre, BScHons, PhD, School of Biological Sciences, University of Reading, Reading, UK. Amsterdam ; Boston : Academic Press, [2015] xii, 377 pages : color illustrations ; 25 cm text txt rdacontent unmediated n rdamedia volume nc rdacarrier Includes bibliographical references and index. Overview and scope: 1. What are the endocrine disrupters and where are they found? / Philippa D. Darbre -- 2. How could endocrine disrupters affect human health? / Philippa D. Darbre. Mechanisms and assay systems: 3. Disrupters of estrogen action and synthesis / Philippa D. Darbre -- 4. Disruptors of androgen action and synthesis / J. Thomas Sanderson -- 5. Disrupters of thyroid hormone action and synthesis / Jenny Odum -- 6. Disruption of other receptor systems: progesterone and glucocorticoid receptors, peroxisome preliferator-activated receptors, pregnane X receptor, and aryl hydrocarbon receptor / Philippa D. Darbre -- 7. Nonmonotonic responses in endocrine disruption / Laura N. Vendenburg. Concerns for human health: 8. Endocrine disruption and female reproductive health / Philippa D. Darbre -- 9. Endocrine disruption and male reproductive health / Philippa D. Darbre -- 10. Endocrine disruption and cancer of reproductive tissues / Philippa D. Darbre, Graeme Williams -- 11. Endocrine disruption of thyroid function: chemicals, mechanisms and toxicopathology / Catherine Sutcliffe, Philip W. Harvey -- 12. Endocrine disruption of adrenocortical function / Philip W. Harvey -- 13. Endocrine disruption of developmental pathways and children's health / Monica K. Silver, John D. Meeker -- 14. Effects of endocrine disrupters on immune function and inflammation / Rodney R. Dietert -- 15. Endocrine disruption and disorders of energy metabolism / Philippa D. Darbre. Public policy and regulatory considerations: 16. An introduction to the challenges for risk assessment of endocrine disrupting chemicals / Philippa D. Darbre -- 17. Regulatory considerations for endocrine disrupters in food / Gerard M. Cooke, Rekha Mehta -- 18. Considerations of endocrine disrupters in drinking water / Rowena H. Gee, Leon S. Rockett, Paul C. Rumsby -- 19. Regulatory considerations for dermal application of endocrine disrupters in personal care products / Philippa D. Darbre, Philip W. Harvey. Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human healthPresents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human healthOffers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations.-- Source othe than Library of Congress. Endocrine disrupting chemicals School of Health Sciences Health Science Endocrine Disruptors Health Science School of Health Sciences Darbre, Philippa D. editor. Publisher description https://www.loc.gov/catdir/enhancements/fy1614/2015932023-d.html 7 cbc copycat 2 ncip 20 y-gencatlg lcc LLB 0 0 lcc 0 0 NFIC KyUCL KyUCL GEN 2020-10-07 Donation 13440.00 RA1224.2 .D82 2015 KyU/2020/7880 2022-02-16 2020-10-22 LLB