On framing the research question and choosing the appropriate research design / Patrick S. Parfrey and Pietro Ravani -- Research ethics for clinical researchers / John D. Harnett and Richard Neuman -- Definitions of bias in clinical research / Geoffrey Warden -- Longitudinal studies 1 : determination of risk / Sean W. Murphy -- Longitudinal studies 2 : modeling data using multivariate analysis / Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey -- Longitudinal studies 3 : data modeling using standard regression models and extensions / Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey -- Longitudinal studies 4 : matching strategies to evaluate risk / Matthew T. James -- Longitudinal studies 5 : development of risk prediction models for patients with chronic disease / Navdeep Tangri and Claudio Rigatto -- Randomized controlled trials 1 : design / Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey -- Randomized controlled trials 2 : analysis / Robert N. Foley -- Randomized controlled trials 3 : measurement and analysis of patient-reported outcomes / Michelle M. Richardson, Megan E. Grobert, and Klemens B. Meyer -- Randomized controlled trials 4 : biomarkers and surrogate outcomes / Claudio Rigatto and Brendan J. Barrett -- Randomized controlled trials 5 : determining the sample size and power for clinical trials and cohort studies / Tom Greene -- Randomized controlled trials 6 : on contamination and estimating the actual treatment effect / Patrick S. Parfrey -- Randomized controlled trials 7 : analysis and interpretation of quality-of-life scores / Robert N. Foley and Patrick S. Parfrey -- Randomized controlled trials : planning, monitoring, and execution / Elizabeth Hatfield, Elizabeth Dicks, and Patrick S. Parfrey -- Evaluation of diagnostic tests / John M. Fardy and Brendan J. Barrett -- Qualitative research in clinical epidemiology / Deborah M. Gregory and Christine Y. Way -- Health economics in clinical research / Braden J. Manns -- Clinical genetic research 1 : bias / Susan Stuckless and Patrick S. Parfrey -- Clinical genetic research 2 : genetic epidemiology of complex phenotypes / Darren D. O'Rielly and Proton Rahman -- Clinical genetic research 3 : genetics ELSI (ethical, legal, and social issues) research / Daryl Pullman and Holly Etchegary -- Evidence-based decision-making 1 : critical appraisal / Laurie K. Twells -- Evidence-based decision-making 2: systematic reviews and meta-analysis / Aminu Bello, Natasha Wiebe, Amit Garg, and Marcello Tonelli -- Evidence-based decision-making 3 : health technology assessment / Daria O'Reilly [and 6 others] -- Evidence-based decision-making 4: development and limitations of clinical practice guidelines / Bruce Culleton -- Evidence-based decision-making 5 : translational research / Deborah M. Gregory and Laurie K. Twells -- Evidence-based decision-making 6 : utilization of administrative databases for health services research / Tanvir Turin Chowdhury and Brenda Hemmelgarn -- Evidence-based decision-making 7: knowledge translation / Braden J. Manns -- Evidence-based decision-making 8 : health policy, a primer for researchers / Victor Maddalena.